Postgraduate Seminar Presentation : Online FTIR Analysis of Micro-Scale Multiphase Systems Aided by BTEM

Speaker Lin Rui Eddie (Supervisor: A/Prof Saif A Khan)

Host Department of Chemical and Biomolecular Engineering

Date/Time 07 Dec - 07 Dec, 2.00pm

Venue E5-02-32 , Faculty of Engineering, National University of Singapore


In this work, a simple system for rapid, online chemical analysis via transmission FTIR was assembled; system is shown to be suitable for analyzing single (liquid) phase and multiphase (liquid-liquid segmented) micro (<10 uL.min-1) flow chemistry systems at a temporal resolution of 1 spectra per 1.5 minute. The acquired spectroscopic data was analyzed with BTEM (Band-Target Entropy Minimization) chemometrics algorithm for the deconvolution of mixture spectra to reconstruct pure component spectra estimates of each chemical species. The technique developed is shown to be effective for quantification and qualification of a micro flow fluid stream without a priori knowledge. Finally, the technique was tested on a photo-polymerization system, and shown to be effective for process monitoring. This automated, generalizable, qualitative and quantitative chemical process analysis technique has many practical applications; such as quick prototyping of microfluidic devices and rapid process parameter screening of micro flow systems