Postgraduate Seminar Presentation : Membrane customisable nanomedicine against cancer

Speaker Cansu Sevencan (Supervisor: A/Prof Leong Tai Wei David)

Host Department of Chemical and Biomolecular Engineering

Date/Time 21 May - 21 May, 10.00am

Venue E5-02-32 , Faculty of Engineering, National University of Singapore

Synopsis

The efficacy of the current chemotherapy drugs mainly depends on the existence of some common biomarkers such as EGFR, VEGF and ALK etc. However, only a small percentage of the cancer patients carries these biomarkers. Personalised medicine can achieve efficient therapy for every cancer patient. Over the last few decades nanoparticle based anti-cancer therapeutics attracted great interest due to their favorable size, passive targeting ability and versatile functionalization potential. Coating nanoparticles with patients' cancer cell membrane has been shown to be very effective way to obtain personalised medicine due to homotypic targeting properties of the cancer cell membrane. Based on this knowledge, we hypothesized that coating nanoparticles with cell and organelle membrane can confer extracellular and intracellular targeting ability, even in the situation where the targeting moiety is unknown. Intracellular targeting can help us to achieve enhanced cancer cell killing effect with less number of nanoparticles as precise addressing to the exact organelles is possible and non-dilutive.

Biography