Issue 1 (2014)
Separation of racemic molecules is substantially important in chemical and pharmaceutical industries. In this study, two isostructural chiralmetal-organic frameworks decorated with chiral di-hydroxy or -methoxy auxiliares in the channels are designed and synthesized from enantiopure tetracarboxylate bridging ligands of 1,1′-biphenol and a manganese carboxylate infinite chain. The frameworks...
A genome-scale metabolic model of Methanococcus maripaludis S2 for CO2 capture and conversion to methane
Increasing demand of fossil fuels worldwide encourages production of renewable chemicals and fuels from CO2 consuming microorganisms. Methane production from CO2 by methanogens is widely known in nature. M. maripaludis S2 is a fully sequenced hydrogenotrophic methanogen and an excellent laboratory strain with robust genetic tools. However, a quantitative systems biology model to complement these...
Iftekhar Abubakar KARIMI
Nanoparticles can have profound eﬀects on cell biology. Here, we show that after TiO2, SiO2, and hydroxyapatite nanoparticles treatment, TR146 epithelial cell sheet displayed slower migration. Cells after exposure to the nanoparticles showed increased cell contractility with signiﬁcantly impaired wound healing capability however without any apparent cytotoxicity. We showed the mechanism is...
David Tai Wei LEONG
Engineering of P450pyr hydroxylase for highly regio- and enantioselective subterminal hydroxylation of alkane
Terminal selective cytochrome P450pyr has been successfully engineered via directed evolution for the subterminal hydroxylation of alkane at non-activated carbon atom with excellent regio- and enantioselectivity. A novel, accurate, and sensitive colorimetric high-throughput screening (HTS) assay was developed for measuring both regioselectivity and enantioselectivity for a hydroxylation...
Unusual behavior of propane as a co-guest during hydrate formation in silica sand: Application to seawater Desalination
Recently, we identified an unusual behavior of hydrate formation in silica sand with gas mixtures containing propane as a co-guest. Based on morphology study we observed that propane as a co-guest has the ability to draw water dispersed in silica sand to the hydrate formation region and showed a tendency to result in drastic hydrate growth due to the migration of water molecules to the gas...
Nanomaterials that combine diagnostic and therapeutic functions within a single nanoplatform are highly desirable for molecular medicine. Herein we report a novel theranostic platform based on a conjugated polyelectrolyte (CPE) polyprodrug that contains the functionality for imaging, chemo- and photodynamic therapy (PDT) and on-demand drug release upon single light irradiation. Specifically,...
Heat exchanger network (HEN) retrofitting improves heat recovery and reuse in existing plants, by either adding heat transfer area and/or using heat transfer enhancements to enhance heat transfer coefficients. There is an increasing interest in HEN retrofitting as can be seen from 20 journal papers in the last 5 years. In total, there are about 60 journal papers on HEN retrofitting since the...
Gade Pandu RANGAIAH
Radiotherapy remains a major modality in cancer therapy; up to 50% patients are treated with radiotherapy during their battle against cancer. Though high-energy radiation can fatally damage tumor cells, it often kills healthy cells and causes toxicity to the patient. The use of radiosensitizers to increase the local treatment efficacy under a relatively low and safe radiation dose is the most...
A new route has been developed for chitin utilization, which is featured as the front cover of ACS Sustainable Chemistry & Engineering Chitin is the most abundant N-containing biomass materials obtained from mainly the shells of crabs and shrimps. By using sulphuric acid as the catalyst in ethylene glycol solvent, the white, solid-state chitin is transformed into brown/yellow oils comprising of...
Simultaneous synthesis and assembly of noble metal nanoclusters (NCs) into mesoscale structures are achieved using their metal halides, cetyltrimethylammonium bromide (CTAB) and thiourea. Geometric shape, hierarchical organization and packing density of resultant assemblages vary depending on metal precursors and CTAB concentration. Rod- or tube-like assemblagesare formed from Au NCs, giant...
Hua Chun ZENG